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Chemical structure of Fmoc-Tyr-Ala-diazomethylketone

GA21834

Fmoc-Tyr-Ala-diazomethylketone

Also known as 9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-4-diazo-3-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamate

Fmoc-Tyr-Ala-diazomethylketone inhibited cathepsins B, L, and S with similar kinetics· Fmoc-YA-DMK was shown to react irreversibly with cathepsins B and L, but not with cathepsin S and was able to penetrate cells and to react with active enzymes within the cells

ChemicalCAS205763-22-0MW498.54FormulaC28H26N4O5
CAS number
205763-22-0
Molecular weight
498.54
Formula
C28H26N4O5
Solubility
Soluble in DMSO
InChIKey
RYXAYZBFIBMXRV-GKVSMKOHSA-N
Catalogue number
GA21834
Brand
GLPBIO
Computed properties PubChem CID 92489559 · XLogP 4.2 · TPSA 107 Ų · H-bond donors 3
XLogP
4.2
TPSA
107 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
10
Heavy atoms
37

SMILES C[C@@H](C(=O)C=[N+]=[N-])NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Computed descriptors from PubChem (CID 92489559), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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