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Chemical structure of Fmoc-Ala-(Dmb)Gly-OH

GA21499

Fmoc-Ala-(Dmb)Gly-OH

Also known as 2-[(2,4-dimethoxyphenyl)methyl-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoyl]amino]acetic acid

Introduction of the Dmb-moiety disrupts aggregated sequences during Fmoc-SPPS as efficiently as a pseudoproline residue· Dmb dipeptides couple smoothly, as, contrary to Hmb dipeptides, they cannot form oxazepinones· Dmb is removed during the final TFA cleavage in the presence of scavengers

ChemicalCAS1188402-17-6MW518.57FormulaC29H30N2O7
CAS number
1188402-17-6
Molecular weight
518.57
Formula
C29H30N2O7
Solubility
Soluble in DMSO
InChIKey
AWDFPJNCCCPIHR-SFHVURJKSA-N
Catalogue number
GA21499
Brand
GLPBIO
Computed properties PubChem CID 95565924 · XLogP 4 · TPSA 114 Ų · H-bond donors 2
XLogP
4
TPSA
114 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
38

SMILES C[C@@H](C(=O)N(CC1=C(C=C(C=C1)OC)OC)CC(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Computed descriptors from PubChem (CID 95565924), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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