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Chemical structure of Fmoc-4-(neopentyloxysulfonyl)-Abu-OH

GA21482

Fmoc-4-(neopentyloxysulfonyl)-Abu-OH

Also known as (2S)-4-(2,2-dimethylpropoxysulfonyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid

Orthogonally protected derivative of homocysteic acid· As a Glu substitute, or for introducing a highly acidic moiety, it can be incorporated into various peptide effectors, such as receptor ligands and enzyme inhibitors· The neopentyl sulfonate can be cleaved with HF/m-cresol or by slow hydrolysis in 0·1% TFA in water/acetonitrile· This cysteic acid homolog occurs in nature; homocysteic acid, generated from plasma homocysteine, can damage endothelial tissue

ChemicalCAS220951-81-5MW475.56FormulaC24H29NO7S
CAS number
220951-81-5
Molecular weight
475.56
Formula
C24H29NO7S
Solubility
Soluble in DMSO
InChIKey
TYNFNWKIJOXRLL-NRFANRHFSA-N
Catalogue number
GA21482
Brand
GLPBIO
Computed properties PubChem CID 11798761 · XLogP 4.2 · TPSA 127 Ų · H-bond donors 2
XLogP
4.2
TPSA
127 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
33

SMILES CC(C)(C)COS(=O)(=O)CC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Computed descriptors from PubChem (CID 11798761), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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