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Chemical structure of Fluorogenic Human CMV Protease Substrate

GA21468

Fluorogenic Human CMV Protease Substrate

Also known as 5-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-5-carbamimidamido-2-[[4-[[4-(dimethylamino)phenyl]diazenyl]benzoyl]amino]pentanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]ethylamino]naphthalene-1-sulfonic acid

The FRET substrate Dabcyl-RGVVNASSRLA-Edans has been synthesized to develop a fluorescence-based assay of human cytomegalovirus proteinase· It is cleaved specifically at the Ala-Ser bond thereby liberating the C-terminal peptide-EDANS fragment from the proximity quenching effect of the DABCYL group· This represents the first fluorescence-based assay of the herpes virus proteases and permits the characterization of potential inhibitors· Cleavage yields the N-terminal fragment H-2442

ChemicalCAS163265-38-1MW1628.88FormulaC73H109N23O18S
CAS number
163265-38-1
Molecular weight
1628.88
Formula
C73H109N23O18S
Solubility
Soluble in DMSO
InChIKey
AJDKLTODLUQZKG-MYCAOZRRSA-N
Catalogue number
GA21468
Brand
GLPBIO
Computed properties PubChem CID 102602013 · XLogP -0.4 · TPSA 659 Ų · H-bond donors 23
XLogP
-0.4
TPSA
659 Ų
H-bond donors
23
H-bond acceptors
24
Rotatable bonds
49
Heavy atoms
115

SMILES C[C@@H](C(=O)NCCNC1=CC=CC2=C1C=CC=C2S(=O)(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)C3=CC=C(C=C3)N=NC4=CC=C(C=C4)N(C)C

Computed descriptors from PubChem (CID 102602013), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.