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Chemical structure of ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])

GA21423

ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])

This all-D peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682) corresponding to amino acids 16 to 20 of amyloid β-protein· The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1·3 · 10?² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1·1 ± 0·3 µM)· It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures

ChemicalCAS1426174-31-3MW1486.91FormulaC79H119N15O13
CAS number
1426174-31-3
Molecular weight
1486.91
Formula
C79H119N15O13
Solubility
Soluble in DMSO
Catalogue number
GA21423
Brand
GLPBIO

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