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Chemical structure of Endotoxin Inhibitor

GA21420

Endotoxin Inhibitor

Also known as (4R,7S,10S,13S,16S,19S,22R)-7,10,19-tris(4-aminobutyl)-22-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-16-benzyl-13-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxylic acid

The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0·56 · 10? M?¹· It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo· Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases·KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B· It could be of use as an adjuvant for antibiotic therapy

ChemicalCAS147396-10-9MW1224.6FormulaC55H97N15O12S2
CAS number
147396-10-9
Molecular weight
1224.6
Formula
C55H97N15O12S2
Solubility
Soluble in DMSO
InChIKey
ZMJQAGFRHOLBKF-IYXJEWLDSA-N
Catalogue number
GA21420
Brand
GLPBIO
Computed properties PubChem CID 11981190 · XLogP -4.4 · TPSA 526 Ų · H-bond donors 17
XLogP
-4.4
TPSA
526 Ų
H-bond donors
17
H-bond acceptors
20
Rotatable bonds
32
Heavy atoms
84

SMILES C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCCN)CC2=CC=CC=C2)CC(C)C)CCCCN)CCCCN)C(=O)O)NC(=O)[C@H](CCCCN)N)O

Computed descriptors from PubChem (CID 11981190), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.