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Chemical structure of Dendroaspis Natriuretic Peptide

GA21375

Dendroaspis Natriuretic Peptide

Also known as (4S)-4-amino-5-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(4R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,43S,49S,52R)-40-(4-aminobutyl)-4-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-4-amino-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-carboxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-13,25-bis(2-amino-2-oxoethyl)-49-benzyl-28,37-bis[(2S)-butan-2-yl]-31-(3-carbamimidamidopropyl)-34-(carboxymethyl)-16-(hydroxymethyl)-22,43-bis(1H-imidazol-4-ylmethyl)-10-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-hexadecaoxo-19-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecazacyclotripentacont-52-yl]carbamoyl]pyrrolidin-1-yl]-3-carboxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

The 38 amino acid peptide DNP, which has been originally isolated from the venom of the green mamba snake (Dendroaspis angusticeps), shares structural homology with the family of natriuretic peptides· DNP contains a 17 amino acid disulfide ring similar to ANP, BNP, and CNP, which mediate biological actions through particulate guanylyl cyclase receptors and generation of guanosine monophosphate (cGMP)

ChemicalCAS255721-52-9MW4190.69FormulaC180H282N56O56S2
CAS number
255721-52-9
Molecular weight
4190.69
Formula
C180H282N56O56S2
Solubility
Soluble in DMSO
InChIKey
GEDFABJDSBUAHZ-OBNQBNKVSA-N
Catalogue number
GA21375
Brand
GLPBIO
Computed properties PubChem CID 171920853 · XLogP -21.8 · TPSA 1840 Ų · H-bond donors 60
XLogP
-21.8
TPSA
1840 Ų
H-bond donors
60
H-bond acceptors
66
Rotatable bonds
99
Heavy atoms
294

SMILES CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC=N2)CC3=CC=CC=C3)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)N)C(=O)N6CCC[C@H]6C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N7CCC[C@H]7C(=O)N[C@@H](CCCNC(=N)N)C(=O)N8CCC[C@H]8C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N9CCC[C@H]9C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)O)CC(C)C)CC(=O)N)CO)C(C)C)CC1=CNC=N1)CC(=O)N)[C@@H](C)CC)CCCNC(=N)N)CC(=O)O

Computed descriptors from PubChem (CID 171920853), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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