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Chemical structure of Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide

GA21318

Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide

Also known as (3R,6S,12S,15R)-6-(carboxymethyl)-12-[3-(diaminomethylideneamino)propyl]-15-[(4-hydroxyphenyl)methyl]-1,5,8,11,14,17-hexaoxo-1lambda4-thia-4,7,10,13,16-pentazacyclooctadecane-3-carboxylic acid

This sulfur-bridged cyclic RGD peptide is a potent inhibitor of the binding of glycoprotein IIb/IIIa to fibrinogen with an IC?? of 1·5 nM· Furthermore, it is a highly potent inhibitor of fibrinogen-mediated platelet aggregation (IC?? = 0·15 µM)· Its antithrombotic activity in vivo may render this compound useful in the treatment of arterial thromboembolic diseases

ChemicalCAS143120-27-8MW668.69FormulaC26H36N8O11S
CAS number
143120-27-8
Molecular weight
668.69
Formula
C26H36N8O11S
Solubility
Soluble in DMSO
InChIKey
DMXRDQJVBMEHPP-OREKCURGSA-N
Catalogue number
GA21318
Brand
GLPBIO
Computed properties PubChem CID 164450 · XLogP -4.1 · TPSA 341 Ų · H-bond donors 10
XLogP
-4.1
TPSA
341 Ų
H-bond donors
10
H-bond acceptors
13
Rotatable bonds
9
Heavy atoms
46

SMILES C1[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)CS1=O)CC2=CC=C(C=C2)O)CCCN=C(N)N)CC(=O)O)C(=O)O

Computed descriptors from PubChem (CID 164450), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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