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Chemical structure of Cyclo(-Ala-Arg-Gly-Asp-3-aminomethylbenzoyl)

GA21294

Cyclo(-Ala-Arg-Gly-Asp-3-aminomethylbenzoyl)

Also known as 2-[(5S,11S,14S)-11-[3-(diaminomethylideneamino)propyl]-14-methyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentazabicyclo[15.3.1]henicosa-1(21),17,19-trien-5-yl]acetic acid

The small molecule RGD peptidomimetic αvβ3 integrin antagonist XJ-735 contains both anionic and cationic binding sites that straddle the RGD binding domain of the αvβ3 integrin· The IC?? values of XJ 735 for αvβ3-mediated inhibition of human and porcine cell adhesion, and vascular smooth muscle cell migration, ranged from 0·6 to 4·4 µM· In contrast, IC?? for porcine or human αIIb/β3, α4β1, αvβ5, and α5β1 inhibition exceeded 100 µM

ChemicalCAS153381-95-4MW532.56FormulaC23H32N8O7
CAS number
153381-95-4
Molecular weight
532.56
Formula
C23H32N8O7
Solubility
Soluble in DMSO
InChIKey
HRASXYOWQQTBAQ-RCBQFDQVSA-N
Catalogue number
GA21294
Brand
GLPBIO
Computed properties PubChem CID 71312170 · XLogP -2.7 · TPSA 247 Ų · H-bond donors 8
XLogP
-2.7
TPSA
247 Ų
H-bond donors
8
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
38

SMILES C[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC2=CC(=CC=C2)C(=O)N1)CC(=O)O)CCCN=C(N)N

Computed descriptors from PubChem (CID 71312170), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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