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Chemical structure of Collagen Type IV α3 Chain (185-203)

GA21277

Collagen Type IV α3 Chain (185-203)

Also known as (4S)-4-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-5-oxopentanoic acid

The collagen IV fragment CNYYSNSYSFWLASLNPER inhibits the activation of polymorphonuclear leukocytes· It promotes adhesion of human melanoma cells and inhibits their proliferation by 40%· These properties appear to be dependent on the presence of the triplet sequence -Ser-Asn-Ser- (residues 189-191), which is unique in the α3 chain and may represent an important functional epitope

ChemicalCAS157802-35-2MW2314.52FormulaC105H144N26O32S
CAS number
157802-35-2
Molecular weight
2314.52
Formula
C105H144N26O32S
Solubility
Soluble in DMSO
InChIKey
QJWBWCMTAMAKSU-JDDMTDLZSA-N
Catalogue number
GA21277
Brand
GLPBIO
Computed properties PubChem CID 44511378 · XLogP -7.8 · TPSA 965 Ų · H-bond donors 35
XLogP
-7.8
TPSA
965 Ų
H-bond donors
35
H-bond acceptors
35
Rotatable bonds
69
Heavy atoms
164

SMILES C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CC7=CC=C(C=C7)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CS)N

Computed descriptors from PubChem (CID 44511378), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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