GA21253
Cdc25A (80-93) (human)
Also known as (2S)-2-[[(2S)-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]butanedioic acid
The abundance of Cdc25A fluctuates periodically during the cell division cycle, which is primarily modulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, Anaphase Promoting Complex/Cyclosome and Skp1/Cul1/F-box protein· Ubiquitylation and degradation occurs at mitotic exit and in G1 due to the presence of a destruction motif (KEN-box) in Cdc25A, while phosphorylation events regulate Cdc25A protein stability in S phase both in unperturbed cells and in cells exposed to DNA damaging agents or DNA replication inhibitors
- CAS number
- 851538-67-5
- Molecular weight
- 1423.52
- Formula
- C60H90N14O24S
- Solubility
- Soluble in DMSO
- InChIKey
- MISDPONGDAVIAY-KKXVGTAUSA-N
- Catalogue number
- GA21253
- Brand
- GLPBIO
Computed properties PubChem CID 169450552 · XLogP -7.7 · TPSA 598 Ų · H-bond donors 20
- XLogP
- -7.7
- TPSA
- 598 Ų
- H-bond donors
- 20
- H-bond acceptors
- 26
- Rotatable bonds
- 41
- Heavy atoms
- 99
SMILES C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)O)N)O
Computed descriptors from PubChem (CID 169450552), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il