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Chemical structure of Anthranilyl-HIV Protease Substrate

GA20769

Anthranilyl-HIV Protease Substrate

Also known as (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S,3R)-2-[(2-aminobenzoyl)amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-(4-nitrophenyl)propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide

This hexapeptide FRET substrate is derived from the p24/p15 cleavage site of the viral gag-pol poly-protein· A simple, continuous fluorometric assay for HIV protease has been developed, which allows the screening of potential HIV protease inhibitors·Values for Km (2·1 μM) and kcat (7·4 s?¹) were calculated from steady-state data at a low concentration of the enzyme· Excitation at 280 nm, emission at > 435 nm

ChemicalCAS133233-38-2MW940.07FormulaC43H65N13O11
CAS number
133233-38-2
Molecular weight
940.07
Formula
C43H65N13O11
Solubility
Soluble in DMSO
InChIKey
QIBOWTWGRFTPPW-RSLNUCABSA-N
Catalogue number
GA20769
Brand
GLPBIO
Computed properties PubChem CID 457124 · XLogP 0.3 · TPSA 417 Ų · H-bond donors 12
XLogP
0.3
TPSA
417 Ų
H-bond donors
12
H-bond acceptors
13
Rotatable bonds
28
Heavy atoms
67

SMILES CCCC[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)[N+](=O)[O-])C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)O)NC(=O)C2=CC=CC=C2N

Computed descriptors from PubChem (CID 457124), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.