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Chemical structure of Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (669-674)-EDDnp

GA20448

Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (669-674)-EDDnp

Also known as (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[(2-aminobenzoyl)amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-[2-(2,4-dinitroanilino)ethylamino]-5-oxopentanoic acid

Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair· It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity)· This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2)

ChemicalCAS1007306-20-8MW986.99FormulaC42H58N12O16
CAS number
1007306-20-8
Molecular weight
986.99
Formula
C42H58N12O16
Solubility
Soluble in DMSO
InChIKey
GKWQBPUDQYNKGN-YOCSTNKPSA-N
Catalogue number
GA20448
Brand
GLPBIO
Computed properties PubChem CID 131842864 · XLogP 0.8 · TPSA 451 Ų · H-bond donors 12
XLogP
0.8
TPSA
451 Ų
H-bond donors
12
H-bond acceptors
18
Rotatable bonds
27
Heavy atoms
70

SMILES C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)NCCNC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-])NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)C2=CC=CC=C2N

Computed descriptors from PubChem (CID 131842864), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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