GA20443
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK)
This ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the ƒ-amino group of Arg¹, selectively blocked the voltage gated T-lymphocyte K? Kv1·3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis· It potently blocked Kv1·3 channels at picomolar concentrations and exhibited >80 fold specificity for Kv1·3 over Kv1·1 and other Kv channels· In flow cytometry experiments, chronically activated rat and human T-lympocytes with >600 Kv1·3 channels/cell were readily distinguished from resting and acutely activated T-lymphocytes with lower Kv1·3 channel numbers· 6-FAM-AEEAc-Stichodactyla helianthus neurotoxin (ShK) may therefore be a useful tool to detect the presence of T-lymphocytes with high expression of Kv1·3 channels in normal and diseased tissues
- CAS number
- 1927927-42-1
- Molecular weight
- 4558.3
- Formula
- C196H295N55O57S7
- Solubility
- Soluble in DMSO
- Catalogue number
- GA20443
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il