GA20422
4-Methyl-benzhydrylamine resin (200-400 mesh, 0·70-1·30 mmol/g) · HCl
BHA resin turned out to be not sufficiently acid-labile for obtaining peptide amides with sterically hindered C-termini (e·g· Phe, Leu) applying standard cleavage conditions· Introduction of a 4-methyl substituent sufficiently increased the acid-lability of the peptide-resin linkage· Cleavage can be achieved with HF, trifluoromethanesulfonic acid or tetrafluoroboronic acid/thioanisole in TFA using scavengers such as m-cresol and ethanedithiol· This resin has been employed by Pei et al· in the synthesis of quinolinones from β-lactams, and in the conversion of linear peptide amides to cyclic ureas or thioureas
Chemical
- CAS number
- —
- Molecular weight
- —
- Formula
- —
- Solubility
- Soluble in DMSO
- Catalogue number
- GA20422
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il