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Chemical structure of 4-Biphenylac-Cys(Me)-D-Arg-Phe-(2-phenylethyl)amide

GA20414

4-Biphenylac-Cys(Me)-D-Arg-Phe-(2-phenylethyl)amide

Also known as (2R)-5-(diaminomethylideneamino)-2-[[(2R)-3-methylsulfanyl-2-[[2-(4-phenylphenyl)acetyl]amino]propanoyl]amino]-N-[(2S)-1-oxo-3-phenyl-1-(2-phenylethylamino)propan-2-yl]pentanamide

Cathepsin L inhibitor VI, inhibitor with nanomolar potency (Ki = 19 nM) and higher selectivity for inhibiting cathepsin L over cathepsin K (310-fold) and cathepsin B (210-fold)· The tripeptide-sized inhibitor mimicks the mode of autoinhibition of procathepsin L

ChemicalCAS478164-48-6MW735.95FormulaC41H49N7O4S
CAS number
478164-48-6
Molecular weight
735.95
Formula
C41H49N7O4S
Solubility
Soluble in DMSO
InChIKey
UYRQVAFRIYOHSH-SBPNQFBHSA-N
Catalogue number
GA20414
Brand
GLPBIO
Computed properties PubChem CID 9918384 · XLogP 4.6 · TPSA 206 Ų · H-bond donors 6
XLogP
4.6
TPSA
206 Ų
H-bond donors
6
H-bond acceptors
6
Rotatable bonds
20
Heavy atoms
53

SMILES CSC[C@@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCCC2=CC=CC=C2)NC(=O)CC3=CC=C(C=C3)C4=CC=CC=C4

Computed descriptors from PubChem (CID 9918384), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.