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Chemical structure of (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110

GA20343

(Z-Asp-Glu-Val-Asp)₂-Rhodamine 110

Also known as (4S)-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[6'-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]butanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-3-carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoic acid

(Z-DEVD)?-R110, highly sensitive, photostable fluorogenic substrate for the determination of intracellular caspase-3 activity· The fluorophore Rhodamine 110 (R110) can be detected at an emission wavelength of 535 nm using an excitation wavelength of 485 nm· As with (H-Asp-Glu-Val-Asp)?-Rhodamine 110 (M-2620) the fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy

ChemicalCAS223538-61-2MW1515.46FormulaC72H78N10O27
CAS number
223538-61-2
Molecular weight
1515.46
Formula
C72H78N10O27
Solubility
Soluble in DMSO
InChIKey
MRLMIVOGDRELQK-DLODMIPSSA-N
Catalogue number
GA20343
Brand
GLPBIO
Computed properties PubChem CID 16181078 · XLogP 1.7 · TPSA 569 Ų · H-bond donors 16
XLogP
1.7
TPSA
569 Ų
H-bond donors
16
H-bond acceptors
27
Rotatable bonds
40
Heavy atoms
109

SMILES CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)OCC5=CC=CC=C5)C6=CC=CC=C6C(=O)O3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)OCC7=CC=CC=C7

Computed descriptors from PubChem (CID 16181078), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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