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Chemical structure of (Ser(PO₃H₂)²⁷³)-Nek11 (268-283)

GA20300

(Ser(PO₃H₂)²⁷³)-Nek11 (268-283)

Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A, both in unperturbed and DNA-damaged cells· In addition, NEK11 directly phosphorylates CDC25A, and CHK1 (checkpoint kinase 1) directly activates NEK11 by phosphorylating it on Ser²?³· Taken together, NEK11 is an important component of the pathway enforcing the G2/M checkpoint, and genetic mutations in NEK11 may contribute to the development of cancer· These results have been shown by Melixetian and coworkers

ChemicalMW1848.09FormulaC77H135N22O26PS
CAS number
—
Molecular weight
1848.09
Formula
C77H135N22O26PS
Solubility
Soluble in DMSO
Catalogue number
GA20300
Brand
GLPBIO

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.