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Chemical structure of (Pyr³)-Amyloid β-Protein (3-40)

GA20283

(Pyr³)-Amyloid β-Protein (3-40)

The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity· Aβ40 and 42 can be N-terminally truncated by action of cathepsin B· The cyclization of Glu³ is catalyzed by glutaminyl cyclase· Hence, inhibition of these enzymes could be a therapeutic approach to AD

ChemicalCAS161818-04-8MW4125.68FormulaC187H283N51O53S
CAS number
161818-04-8
Molecular weight
4125.68
Formula
C187H283N51O53S
Solubility
Soluble in DMSO
Catalogue number
GA20283
Brand
GLPBIO

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.