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Chemical structure of Disomotide

GA20255

Disomotide

Also listed as (Met¹⁸⁶)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)

This modified sequence of the gp100 epitope gp(209-217) (H-4106), in which a methionine replaced the natural threonine at position 2, bound to the HLA-A2 molecule with greater affinity than the unmodified peptide and was shown to have an increased ability to generate melanoma-reactive cytotoxic T lymphocytes (CTLs) in vitro when used for sensitization of peripheral blood mononuclear cells· This synthetic peptide hold promise for the development of novel cancer immunotherapies

ChemicalCAS181477-43-0MW1035.23FormulaC47H74N10O14S
CAS number
181477-43-0
Molecular weight
1035.23
Formula
C47H74N10O14S
Solubility
Soluble in DMSO
InChIKey
BDQMCYCLZBSYJZ-BBXCZNCNSA-N
Catalogue number
GA20255
Brand
GLPBIO
Computed properties PubChem CID 657090 · XLogP -2.3 · TPSA 413 Ų · H-bond donors 12
XLogP
-2.3
TPSA
413 Ų
H-bond donors
12
H-bond acceptors
16
Rotatable bonds
31
Heavy atoms
72

SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)O)N

Computed descriptors from PubChem (CID 657090), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.