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Chemical structure of Cyclo(-Glu-Met-Thr-Hyp-Val-Asn-Hyp-Gly-Gln)

GA20223

Cyclo(-Glu-Met-Thr-Hyp-Val-Asn-Hyp-Gly-Gln)

Also listed as (Hyp⁴⁷⁴,⁴⁷⁷,Gln⁴⁷⁹)-cyclo-α-Fetoprotein (471-479) (human, lowland gorilla)

The cyclic α-fetoprotein-derived peptide analog efficiently inhibited the growth of estrogen-dependent MCF-7 human breast cancer cell xenografts· The extent of inhibition was similar to that of tamoxifen· In contrast to tamoxifen the peptide did not interfere with estrogen binding to its receptor and therefore further development of this compound might yield a new class of valuable agents for the effective treatment of breast cancer

ChemicalCAS393827-70-8MW986.07FormulaC40H63N11O16S
CAS number
393827-70-8
Molecular weight
986.07
Formula
C40H63N11O16S
Solubility
Soluble in DMSO
InChIKey
SNCLBDOCRFHUHM-BUROXXGJSA-N
Catalogue number
GA20223
Brand
GLPBIO
Computed properties PubChem CID 11051348 · XLogP -5.7 · TPSA 454 Ų · H-bond donors 13
XLogP
-5.7
TPSA
454 Ų
H-bond donors
13
H-bond acceptors
17
Rotatable bonds
13
Heavy atoms
68

SMILES C[C@H]([C@H]1C(=O)N2C[C@@H](C[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@@H](C[C@H]3C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCSC)CCC(=O)O)CCC(=O)N)O)CC(=O)N)C(C)C)O)O

Computed descriptors from PubChem (CID 11051348), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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