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Chemical structure of (His³²,Leu³⁴)-Neuropeptide Y (32-36)

GA20219

(His³²,Leu³⁴)-Neuropeptide Y (32-36)

Also known as (2S)-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanamide

The inactive NPY carboxy-terminal pentapeptide (IC?? > 100 µM) was modified by replacing threonine with histidine and glutamine with leucine· The resulting peptide had a dramatically improved affinity (IC?? = 0·45 µM) for the rat brain receptor

ChemicalCAS168916-68-5MW742.88FormulaC33H54N14O6
CAS number
168916-68-5
Molecular weight
742.88
Formula
C33H54N14O6
Solubility
Soluble in DMSO
InChIKey
IVILZDFWVWZRQG-LROMGURASA-N
Catalogue number
GA20219
Brand
GLPBIO
Computed properties PubChem CID 10372859 · XLogP -2.5 · TPSA 363 Ų · H-bond donors 12
XLogP
-2.5
TPSA
363 Ų
H-bond donors
12
H-bond acceptors
10
Rotatable bonds
23
Heavy atoms
53

SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC2=CN=CN2)N

Computed descriptors from PubChem (CID 10372859), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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