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Chemical structure of (Glu²)-TRH

GA20189

(Glu²)-TRH

Also known as (4S)-5-[(2S)-2-carbamoylpyrrolidin-1-yl]-5-oxo-4-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoic acid

Fertilization-promoting peptide (FPP), a TRH analog, was previously purified and characterized from both rabbit prostate and human semen· Nanomolar concentrations of this peptide have been shown to enhance capacitation of mouse epididymal spermatozoa with a concomitant increase in fertilizing ability· It was also detected in the thyroid gland·According to a study of Nguyen et al· Pyr-Glu-Pro-NH? opposes the cholinergic effect of TRH in the mammalian CNS: Co-perfusion with an equivalent of TRH in the rat hippocampus resulted in a significant attenuation of TRH-induced acetylcholine release

ChemicalCAS85541-78-2MW354.36FormulaC15H22N4O6
CAS number
85541-78-2
Molecular weight
354.36
Formula
C15H22N4O6
Solubility
DMSO ： 100 mg/mL (282·20 mM; Need ultrasonic)
InChIKey
HYZBGWLLSXSYLX-GUBZILKMSA-N
Catalogue number
GA20189
Brand
GLPBIO
Computed properties PubChem CID 122148 · XLogP -2.7 · TPSA 159 Ų · H-bond donors 4
XLogP
-2.7
TPSA
159 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
25

SMILES C1C[C@H](N(C1)C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CCC(=O)N2)C(=O)N

Computed descriptors from PubChem (CID 122148), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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