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Chemical structure of (D-Arg²)-Dermorphin (1-4) amide

GA20075

(D-Arg²)-Dermorphin (1-4) amide

Also known as (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide

YrFG-amide, which is more stable to enzymatic cleavage, is the most potent of the (D-Arg²)-dermorphin fragments· It produces significant antinociception in morphinetolerant mice

ChemicalCAS100304-60-7MW540.62FormulaC26H36N8O5
CAS number
100304-60-7
Molecular weight
540.62
Formula
C26H36N8O5
Solubility
Soluble in DMSO
InChIKey
LAPUTHYQVDIYFG-ACRUOGEOSA-N
Catalogue number
GA20075
Brand
GLPBIO
Computed properties PubChem CID 127510 · XLogP -1.7 · TPSA 241 Ų · H-bond donors 8
XLogP
-1.7
TPSA
241 Ų
H-bond donors
8
H-bond acceptors
7
Rotatable bonds
15
Heavy atoms
39

SMILES C1=CC=C(C=C1)C[C@@H](C(=O)NCC(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)N

Computed descriptors from PubChem (CID 127510), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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