Conjugated RACK1 Rabbit mAb

Target background

Target: Small ribosomal subunit protein RACK1 (RACK1) · Homo sapiens

Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation.

Subcellular location: Cell membrane; Cytoplasm; Cytoplasm, perinuclear region; Nucleus; Perikaryon; Cell projection, dendrite; Cell projection, phagocytic cup

Tissue specificity: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue

Sequence length: 317 aa · 35077 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.