Conjugated Factor H Rabbit mAb

Target background

Target: Complement factor H (CFH) · Homo sapiens

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b.

Subcellular location: Secreted

Tissue specificity: Expressed in the retinal pigment epithelium (at protein level). CFH is one of the most abundant complement components in blood where the liver is the major source of CFH protein in vivo. in addition, CFH is secreted by additional cell types including monocytes, fibroblasts, or endothelial cells

Sequence length: 1231 aa · 139096 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.