C58997
Conjugated NEDD4-2 Rabbit mAb
Human Mouse Rat Recombinant Rabbit
- Host / source
- Recombinant Rabbit
- Reactivity
- Human Mouse Rat
- Conjugate
- AF Dye
- UniProt ID
- Q96PU5
- Gene
- NEDD4L
- Target organism
- Homo sapiens
- Catalogue number
- C58997
- Brand
- LABO Scientific
- Storage
- Store at 4˚Cin dark for 6 months
Target background
Target: E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) · Homo sapiens
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels.
Subcellular location: Cytoplasm; Golgi apparatus; Endosome, multivesicular body
Tissue specificity: Ubiquitously expressed, with highest levels in prostate, pancreas, and kidney. Expressed in melanocytes
Sequence length: 975 aa · 111932 Da
Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Storage
- Store at 4˚Cin dark for 6 months
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il