Conjugated ILK Rabbit mAb

Target background

Target: Scaffold protein ILK (ILK) · Homo sapiens

Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration. Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation. Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events…

Subcellular location: Cell junction, focal adhesion; Cell membrane; Cell projection, lamellipodium; Cytoplasm, myofibril, sarcomere; Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; C

Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver

Sequence length: 452 aa · 51419 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.