Conjugated KCNA1 Rabbit mAb

Target background

Target: Potassium voltage-gated channel subfamily A member 1 (KCNA1) · Homo sapiens

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.

Subcellular location: Cell membrane; Membrane; Cell projection, axon; Cytoplasmic vesicle; Perikaryon; Endoplasmic reticulum; Cell projection, dendrite; Cell junction; Synapse; Presynaptic cell membrane; Presynapse

Tissue specificity: Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level). Detected in the islet of Langerhans

Sequence length: 495 aa · 56466 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.