Conjugated LGR5/GPR49 Rabbit mAb

Target background

Target: Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) · Homo sapiens

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal.

Subcellular location: Cell membrane; Golgi apparatus, trans-Golgi network membrane

Tissue specificity: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver

Sequence length: 907 aa · 99998 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.