Conjugated Prostaglandin D Synthase Rabbit mAb

Target background

Target: Prostaglandin-H2 D-isomerase (PTGDS) · Homo sapiens

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter.

Subcellular location: Rough endoplasmic reticulum; Nucleus membrane; Golgi apparatus; Cytoplasm, perinuclear region; Secreted

Tissue specificity: Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid.

Sequence length: 190 aa · 21029 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.