Conjugated IGF2BP1 Rabbit mAb

Target background

Target: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) · Homo sapiens

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons.

Subcellular location: Nucleus; Cytoplasm; Cytoplasm, perinuclear region; Cytoplasm, P-body; Cytoplasm, Stress granule; Cell projection, lamellipodium; Cell projection, dendrite; Cell projection, dendritic spine; Cell proje

Tissue specificity: Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at protein level).

Sequence length: 577 aa · 63481 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.