Conjugated CLIC4 Rabbit mAb

Target background

Target: Chloride intracellular channel protein 4 (CLIC4) · Homo sapiens

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasmic vesicle membrane; Nucleus; Cell membrane; Mitochondrion; Cell junction; Endoplasmic reticulum membrane

Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle

Sequence length: 253 aa · 28772 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.