Conjugated IGF2BP2 Rabbit mAb

Target background

Target: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) · Homo sapiens

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific.

Subcellular location: Nucleus; Cytoplasm; Cytoplasm, P-body; Cytoplasm, Stress granule

Tissue specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas.

Sequence length: 599 aa · 66121 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.