Conjugated CDT2 Rabbit mAb

Target background

Target: Denticleless protein homolog (DTL) · Homo sapiens

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing.

Subcellular location: Nucleus; Nucleus membrane; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome

Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes.

Sequence length: 730 aa · 79468 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.