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Conjugated MDM2 (Phospho-Ser166) Rabbit mAb

C14281

Conjugated MDM2 (Phospho-Ser166) Rabbit mAb

Conjugated MDM2 (Phospho-Ser166) Rabbit mAb (catalogue number C14281) is a recombinant rabbit-derived conjugated primary antibody, reactive with Human samples. It targets E3 ubiquitin-protein ligase Mdm2 (MDM2): E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Supplied as 100ul at ₪1,627.49; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Conjugated Primary AntibodyHostRecombinant RabbitConjugateAF Dye
Host / source
Recombinant Rabbit
Reactivity
Human
Conjugate
AF Dye
UniProt ID
Q00987
Gene
MDM2
Target organism
Homo sapiens
Catalogue number
C14281
Brand
LABO Scientific
Storage
Store at 4˚Cin dark for 6 months

Target background

Target: E3 ubiquitin-protein ligase Mdm2 (MDM2) · Homo sapiens

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53.

Subcellular location: Nucleus, nucleoplasm; Cytoplasm; Nucleus, nucleolus; Nucleus

Tissue specificity: Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues

Sequence length: 491 aa · 55233 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at 4˚Cin dark for 6 months
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.