EAAT3 Rabbit mAb

Target background

Target: Excitatory amino acid transporter 3 (SLC1A1) · Homo sapiens

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli.

Subcellular location: Cell membrane; Apical cell membrane; Synapse, synaptosome; Early endosome membrane; Late endosome membrane; Recycling endosome membrane

Tissue specificity: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers)

Sequence length: 524 aa · 57100 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.