59720
APPL Rabbit mAb
APPL Rabbit mAb (catalogue number 59720) is a recombinant rabbit-derived kdko validated recombinant monoclonal antibody validated for WB IHC ICC/IF, reactive with Human Mouse Rat samples. It targets DCC-interacting protein 13-alpha (APPL1): Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Supplied in 2 pack sizes, from 50ul at ₪1,015.65 to 100ul at ₪1,382.75; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.
- Host / source
- Recombinant Rabbit
- Reactivity
- Human Mouse Rat
- Applications
- WB IHC ICC/IF
- UniProt ID
- Q9UKG1
- Gene
- APPL1
- Target organism
- Homo sapiens
- Catalogue number
- 59720
- Brand
- LABO Scientific
- Storage
- Store at +4˚C short term. Store at -20˚C long term. Avoid freeze / thaw cycle.
Target background
Target: DCC-interacting protein 13-alpha (APPL1) · Homo sapiens
Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages.
Subcellular location: Early endosome membrane; Nucleus; Cytoplasm; Endosome; Cell projection, ruffle; Cytoplasmic vesicle, phagosome
Tissue specificity: High levels in heart, ovary, pancreas and skeletal muscle
Sequence length: 709 aa · 79663 Da
Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Storage
- Store at +4˚C short term. Store at -20˚C long term. Avoid freeze / thaw cycle.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il