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APPBP1 Rabbit mAb

57221

APPBP1 Rabbit mAb

APPBP1 Rabbit mAb (catalogue number 57221) is a rabbit-derived primary antibody validated for WB IP, reactive with Human samples. It targets NEDD8-activating enzyme E1 regulatory subunit (NAE1): Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. Supplied as 100ul at ₪1,627.49; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Human
Applications
WB IP
UniProt ID
Q13564
Gene
NAE1
Target organism
Homo sapiens
Catalogue number
57221
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: NEDD8-activating enzyme E1 regulatory subunit (NAE1) · Homo sapiens

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Subcellular location: Cell membrane

Tissue specificity: Ubiquitous in fetal tissues. Expressed throughout the adult brain

Sequence length: 534 aa · 60246 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.