INDO Rabbit mAb

Target background

Target: Indoleamine 2,3-dioxygenase 1 (IDO1) · Homo sapiens

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity.

Subcellular location: Cytoplasm, cytosol

Tissue specificity: Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma.

Sequence length: 403 aa · 45326 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.