56021
PMEL17 / GP100 Rabbit mAb
PMEL17 / GP100 Rabbit mAb (catalogue number 56021) is a recombinant rabbit-derived primary antibody validated for WB IHC, reactive with Human samples. It targets Melanocyte protein PMEL (PMEL): Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. Supplied in 2 pack sizes, from 50ul at ₪1,015.65 to 100ul at ₪1,382.75; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.
- Host / source
- Recombinant Rabbit
- Reactivity
- Human
- Applications
- WB IHC
- UniProt ID
- P40967
- Gene
- PMEL
- Target organism
- Homo sapiens
- Catalogue number
- 56021
- Brand
- LABO Scientific
- Storage
- Store at -20°C. Avoid freeze/thaw cycles.
Target background
Target: Melanocyte protein PMEL (PMEL) · Homo sapiens
Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation.
Subcellular location: Endoplasmic reticulum membrane; Golgi apparatus, cis-Golgi network membrane; Endosome, multivesicular body; Melanosome; Extracellular vesicle; Secreted
Tissue specificity: Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Overexpressed in melanomas. Some expression was found in dysplastic nevi
Sequence length: 661 aa · 70255 Da
Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Storage
- Store at -20°C. Avoid freeze/thaw cycles.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il