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Optineurin Rabbit mAb

52829

Optineurin Rabbit mAb

Optineurin Rabbit mAb (catalogue number 52829) is a recombinant rabbit-derived primary antibody validated for WB IHC, reactive with Human samples. It targets Optineurin (OPTN): Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Supplied in 2 pack sizes, from 50ul at ₪1,219.60 to 100ul at ₪2,035.38; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRecombinant Rabbit
Host / source
Recombinant Rabbit
Reactivity
Human
Applications
WB IHC
UniProt ID
Q96CV9
Gene
OPTN
Target organism
Homo sapiens
Catalogue number
52829
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Optineurin (OPTN) · Homo sapiens

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve.

Subcellular location: Cytoplasm, perinuclear region; Golgi apparatus; Golgi apparatus, trans-Golgi network; Cytoplasmic vesicle, autophagosome; Cytoplasmic vesicle; Recycling endosome

Tissue specificity: Present in aqueous humor of the eye (at protein level). Expressed in the trabecular meshwork (at protein level). Expressed in nonpigmented ciliary epithelium (at protein level). Expressed at high levels in skeletal muscle, also detected in heart, brain, pancreas, kidney, placenta and liver.

Sequence length: 577 aa · 65922 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.