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APC Rabbit mAb

52713

APC Rabbit mAb

APC Rabbit mAb (catalogue number 52713) is a recombinant rabbit-derived primary antibody validated for Western blot, reactive with Human, Rat samples. It targets Adenomatous polyposis coli protein (APC): Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. Supplied in 2 pack sizes, from 50ul at ₪1,219.60 to 100ul at ₪2,035.38; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRecombinant Rabbit
Host / source
Recombinant Rabbit
Reactivity
Human, Rat
Applications
Western blot
UniProt ID
P25054
Gene
APC
Target organism
Homo sapiens
Catalogue number
52713
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Adenomatous polyposis coli protein (APC) · Homo sapiens

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton. Plays a role in mediating the organization of F-actin into ordered bundles.

Subcellular location: Cell junction, adherens junction; Cytoplasm, cytoskeleton; Cell projection, lamellipodium; Cell projection, ruffle membrane; Cytoplasm; Cell membrane

Tissue specificity: Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver. Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues.

Sequence length: 2843 aa · 311646 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.