Loading...
Mib1 Antibody

49913

Mib1 Antibody

Mib1 Antibody (catalogue number 49913) is a rabbit-derived primary antibody validated for Western blot, Immunocytochemistry, Immunohistochemistry, reactive with Human, Mouse samples. It targets E3 ubiquitin-protein ligase MIB1 (MIB1): E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Supplied in 2 pack sizes, from 50ul at ₪1,219.60 to 100ul at ₪2,035.38; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Human, Mouse
Applications
Western blot Immunocytochemistry Immunohistochemistry
UniProt ID
Q86YT6
Gene
MIB1
Target organism
Homo sapiens
Catalogue number
49913
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: E3 ubiquitin-protein ligase MIB1 (MIB1) · Homo sapiens

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells.

Subcellular location: Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite; Cell membrane

Tissue specificity: Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined

Sequence length: 1006 aa · 110136 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.