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Securin Antibody

49831

Securin Antibody

Securin Antibody (catalogue number 49831) is a rabbit-derived primary antibody validated for Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Flow cytometry, Immunoprecipitation, reactive with Human samples. It targets Securin (PTTG1): Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Supplied in 2 pack sizes, from 50ul at ₪1,219.60 to 100ul at ₪2,035.38; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Human
Applications
Western blot Immunocytochemistry Immunofluorescence Immunohistochemistry Flow cytometry Immunoprecipitation
UniProt ID
O95997
Gene
PTTG1
Target organism
Homo sapiens
Catalogue number
49831
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Securin (PTTG1) · Homo sapiens

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1.

Subcellular location: Cytoplasm; Nucleus

Tissue specificity: Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer

Sequence length: 202 aa · 22024 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.