Loading...
FBXL2 Antibody

48257

FBXL2 Antibody

FBXL2 Antibody (catalogue number 48257) is a rabbit-derived primary antibody validated for Western blot, Immunocytochemistry, Immunohistochemistry, reactive with Human, Mouse, Rat samples. It targets F-box/LRR-repeat protein 2 (FBXL2): Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Supplied in 2 pack sizes, from 50ul at ₪1,219.60 to 100ul at ₪1,749.85; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Human, Mouse, Rat
Applications
Western blot Immunocytochemistry Immunohistochemistry
UniProt ID
Q9UKC9
Gene
FBXL2
Target organism
Homo sapiens
Catalogue number
48257
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: F-box/LRR-repeat protein 2 (FBXL2) · Homo sapiens

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin.

Subcellular location: Membrane

Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas and placenta

Sequence length: 423 aa · 47062 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.