Loading...
β-Catenin Antibody

47993

β-Catenin Antibody

β-Catenin Antibody (catalogue number 47993) is a primary antibody validated for Western blot, Immunocytochemistry, Immunohistochemistry, reactive with Human, Mouse, Rat, zebrafish samples. It targets Catenin beta-1 (Ctnnb1): Key downstream component of the canonical Wnt signaling pathway. Supplied in 2 pack sizes, from 50ul at ₪1,219.60 to 100ul at ₪1,749.85; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary Antibody
Reactivity
Human, Mouse, Rat, zebrafish
Applications
Western blot Immunocytochemistry Immunohistochemistry
UniProt ID
Q02248
Gene
Ctnnb1
Target organism
Mus musculus
Catalogue number
47993
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Catenin beta-1 (Ctnnb1) · Mus musculus

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Also acts as a coactivator for other transcription factors, such as NR5A2.

Subcellular location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton; Cell junction, adherens junction; Cell junction; Cell membrane; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton

Tissue specificity: Expressed in cerebellar granule neurons (at protein level). Expressed in the intestinal epithelium (at protein level). Abundantly expressed in the tooth, skin, lung, kidney, eye and brain with weak expression in the liver and heart

Sequence length: 781 aa · 85471 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.