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Rho guanine nucleotide exchange factor 18 Polyclonal Antibody

42430

Rho guanine nucleotide exchange factor 18 Polyclonal Antibody

Rho guanine nucleotide exchange factor 18 Polyclonal Antibody (catalogue number 42430) is a rabbit-derived primary antibody validated for Western blot, reactive with Human samples. It targets Rho guanine nucleotide exchange factor 18 (ARHGEF18): Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Supplied as 100μg at ₪1,590.78; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Human
Applications
Western blot
UniProt ID
Q6ZSZ5
Gene
ARHGEF18
Target organism
Homo sapiens
Catalogue number
42430
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Rho guanine nucleotide exchange factor 18 (ARHGEF18) · Homo sapiens

Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G protein-coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells

Subcellular location: Cytoplasm; Cytoplasm, cytoskeleton; Cell membrane; Apical cell membrane

Tissue specificity: Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils. Isoform 2: Expressed in eosinophils. Isoform 3: Expressed in eosinophils. Isoform 4: Not detected in eosinophils

Sequence length: 1361 aa · 151642 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.