PKD2 Antibody

Target background

Target: Polycystin-2 (PKD2) · Homo sapiens

Forms a nonselective cation channel. Can function as a homotetrameric ion channel or can form heteromer with PKD1. Displays distinct function depending on its subcellular localization and regulation by its binding partners. In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release.

Subcellular location: Cell projection, cilium membrane; Endoplasmic reticulum membrane; Cell membrane; Basolateral cell membrane; Cytoplasmic vesicle membrane; Golgi apparatus; Vesicle; Secreted, extracellular exosome

Tissue specificity: Detected in fetal and adult kidney. Detected at the thick ascending limb of the loop of Henle, at distal tubules, including the distal convoluted tubule and cortical collecting tubules, with weak staining of the collecting duct. Detected on placenta syncytiotrophoblasts (at protein level).

Sequence length: 968 aa · 109691 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.