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BRCC36 Antibody

24576

BRCC36 Antibody

BRCC36 Antibody (catalogue number 24576) is a rabbit-derived primary antibody validated for ELISA WB IHC, reactive with Hu Ms Rt samples. It targets Lys-63-specific deubiquitinase BRCC36 (BRCC3): Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Supplied as 100ul at ₪2,157.75; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Hu Ms Rt
Applications
ELISA WB IHC
UniProt ID
P46736
Gene
BRCC3
Target organism
Homo sapiens
Catalogue number
24576
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Lys-63-specific deubiquitinase BRCC36 (BRCC3) · Homo sapiens

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs).

Subcellular location: Nucleus; Cytoplasm; Cytoplasm, cytoskeleton, spindle pole

Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors

Sequence length: 316 aa · 36072 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.